PXD028531 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Trans cohorts metabolic reprograming towards glutaminolysis in long-term successfully treated HIV-Infection: potential role in accelerated aging and latency reversal |
Description | Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon and India, respectively to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids were observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-24 |
AnnouncementXML | Submission_2021-11-24_12:34:04.290.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JIMMY RODRIGUEZ |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-16 06:41:50 | ID requested | |
⏵ 1 | 2021-11-24 12:34:04 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Glutaminolysis, HIV-infection, aging, latency, antiretroviral therapy |
Contact List
Akos Vegvari |
contact affiliation | Division of Chemistry I, Department of Medical Biochemistr and Biophysics, Karolinska Institutet, Campus Solna, 17165 Stockholm, Sweden |
contact email | akos.vegvari@ki.se |
lab head | |
JIMMY RODRIGUEZ |
contact affiliation | Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden |
contact email | esneider007@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028531
- Label: PRIDE project
- Name: Trans cohorts metabolic reprograming towards glutaminolysis in long-term successfully treated HIV-Infection: potential role in accelerated aging and latency reversal