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PXD028531

PXD028531 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTrans cohorts metabolic reprograming towards glutaminolysis in long-term successfully treated HIV-Infection: potential role in accelerated aging and latency reversal
DescriptionDespite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon and India, respectively to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids were observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells.
HostingRepositoryPRIDE
AnnounceDate2021-11-24
AnnouncementXMLSubmission_2021-11-24_12:34:04.290.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJIMMY RODRIGUEZ
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-16 06:41:50ID requested
12021-11-24 12:34:04announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Glutaminolysis, HIV-infection, aging, latency, antiretroviral therapy
Contact List
Akos Vegvari
contact affiliationDivision of Chemistry I, Department of Medical Biochemistr and Biophysics, Karolinska Institutet, Campus Solna, 17165 Stockholm, Sweden
contact emailakos.vegvari@ki.se
lab head
JIMMY RODRIGUEZ
contact affiliationDivision of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
contact emailesneider007@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
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