PXD028487

PXD028487 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy
Description	SIRT1 chromatin interactome analysis was performed to identify SIRT1 molecular targets involved in replication initiation from cells containing either WT or H363Y SIRT1. Co-IP-MS of pT530 SIRT1 from chromatin extracts was performed. Files are: 1422 WT SIRT1 untreated U2OS; 1423 WT SIRT1 H2O2 treated, U2OS; 1424 H363Y SIRT1 untreated U2OS; 1425 H363Y SIRT1 H2O2 U2OS; 1426 KO SIRT1 untreated U2OS; 1427 KO SIRT1 H2O2 U2OS; 1428 WT SIRT1 untreated HEK; 1429 WT SIRT1 H2O2 HEK; 1430 WT SIRT1 untreated HCT116; 1431 WT SIRT1 H2O2 HCT116; 1432 WT SIRT1 untreated K562; 1433 WT SIRT1 H2O2 K562. Each sample has 9 fractions.
HostingRepository	MassIVE
AnnounceDate	2022-11-15
AnnouncementXML	Submission_2022-11-15_07:10:21.214.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lisa Jenkins
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Oxidation
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-15 18:52:40	ID requested
⏵ 1	2022-11-15 07:10:22	announced

Publication List

Thakur BL, Baris AM, Fu H, Redon CE, Pongor LS, Mosavarpour S, Gross JM, Jang SM, Sebastian R, Utani K, Jenkins LM, Indig FE, Aladjem MI, Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy. Nucleic Acids Res, 50(9):5111-5128(2022) [pubmed]

Thakur BL, Baris AM, Fu H, Redon CE, Pongor LS, Mosavarpour S, Gross JM, Jang SM, Sebastian R, Utani K, Jenkins LM, Indig FE, Aladjem MI, Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy. Nucleic Acids Res, 50(9):5111-5128(2022) [pubmed]

Keyword List

submitter keyword: SIRT1 interactome

submitter keyword: SIRT1 interactome

Contact List

Lisa Jenkins
contact affiliation	NCI, NIH
contact email	jenkinsl@mail.nih.gov
lab head
Lisa Jenkins
contact affiliation	NCI
contact email	jenkinsl@mail.nih.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088103/