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PXD028477

PXD028477 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMycobacterium tuberculosis fingerprint in human lungs
DescriptionTuberculosis (TB) is one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent. Globally, an estimated of 10 million people developed TB in 2018 according to WHO report. An estimated one third of all TB cases are not diagnosed or notified, partly due to the major limitations of current diagnostic tools. To achieve the goals of the WHO’s End TB Strategy, which targets for 2030 a 90% reduction in the number of TB deaths and an 80% reduction in the TB incidence rate compared with levels in 2015, diagnostic tools are critically important. Among the three diagnostic priorities identified by the WHO and the TB community is the development of a point-of-care biomarker-based non-sputum-based test to diagnose pulmonary TB, and ideally also extrapulmonary TB. To be successfully implemented at point-of-cares, a new test should use an easily accessible sample, such as urine, blood or breath condensate. Here, we explored whether bacilli-derived molecules released in the extracellular milieu during infection could be detected in the exhaled breath condensate, allowing a specific diagnosis of TB. Interestingly, we detected by proteomic analysis a set of Mycobacterium tuberculosis proteins in all smear-positive and smear-negative adult patients, as well as of children with TB
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:08:36.490.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexandre STELLA
SpeciesList scientific name: Mycobacterium tuberculosis; NCBI TaxID: NCBITaxon:1773; scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-15 09:01:40ID requested
12023-03-10 18:05:39announced
22023-11-14 08:08:37announced2023-11-14: Updated project metadata.
Publication List
Mosquera-Restrepo SF, Zuberogo, ï, tia S, Gouxette L, Layre E, Gilleron M, Stella A, Rengel D, Burlet-Schiltz O, Caro AC, Garcia LF, Segura C, Pel, á, ez Jaramillo CA, Rojas M, Nigou J, A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection. Nat Commun, 13(1):7751(2022) [pubmed]
Keyword List
submitter keyword: lipid,Tuberculosis, Exhaled breath condensate, diagnosis, lipoarabinomannan, protein
Contact List
Jerome Nigou
contact affiliationUMR5089 CNRS Universite de Toulouse IPBS France
contact emailjerome.nigou@ipbs.fr
lab head
Alexandre STELLA
contact affiliationCNRS
contact emailalexandre.stella@ipbs.fr
dataset submitter
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Dataset FTP location
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PRIDE project URI
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