PXD028438

PXD028438 is an original dataset announced via ProteomeXchange.

Title	Extracellular vesicles are crucial mediators in orchestrating brain development and disease
Description	Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiological characterization, dynamic and function of human EVs during human brain development using human-derived cerebral organoids, neural progenitors, neurons and astrocytes. We examined the composition and function of EVs, in patients with myoclonic epilepsy and find alterations in size, composition and function. This study sheds new light on the biology of EVs during brain development.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:03:59.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giuseppina Maccarrone
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 13:55:20	ID requested
1	2023-07-20 13:57:59	announced
⏵ 2	2023-11-14 09:04:00	announced	2023-11-14: Updated project metadata.

Pipicelli F, Baumann N, Di Giaimo R, Forero-Echeverry A, Kyrousi C, Bonrath R, Maccarrone G, Jabaudon D, Cappello S, Non-cell-autonomous regulation of interneuron specification mediated by extracellular vesicles. Sci Adv, 9(20):eadd8164(2023) [pubmed]

submitter keyword: Cerebral organoids, Neurodevelopmental disease, LC-MSMS, Brain development,Extracellular vesicles, CSTB

Silvia Cappello
contact affiliation	Developmental Neurobiology, Max Planck Institute of Psychiatry, Munich, Germany
contact email	silvia_cappello@psych.mpg.de
lab head
Giuseppina Maccarrone
contact affiliation	Max Planck Institute of Psychiatry
contact email	maccarrone@psych.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD028438

PRIDE project URI

• PRIDE
  1. PXD028438
     1. Label: PRIDE project
     2. Name: Extracellular vesicles are crucial mediators in orchestrating brain development and disease