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PXD028403

PXD028403 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleB cell-derived GABA elicits IL-10+ macrophages and limits anti-tumor immunity
DescriptionSmall, soluble metabolites are not only essential intermediates in intracellular biochemical processes, but can also influence neighboring cells when released into the extracellular milieu. Here, we identify the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages which secrete IL-10 and inhibit CD8+ T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA generating enzyme GAD67 enhances anti-tumor responses. Our study reveals that in addition to cytokines and membrane proteins, small metabolites derived from B lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses.
HostingRepositoryPRIDE
AnnounceDate2021-11-15
AnnouncementXMLSubmission_2021-12-02_07:16:28.844.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMidy Wu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-09 09:00:34ID requested
12021-11-15 03:47:39announced
22021-12-02 07:16:29announced2021-12-02: Updated publication reference for PubMed record(s): 34732892.
Publication List
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S, limit anti-tumour immunity. Nature, 599(7885):471-476(2021) [pubmed]
Keyword List
submitter keyword: GABA, B cells, macrophages, anti-tumor immunity
Contact List
Sidonia Fagarasan
contact affiliationLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan
contact emailsidonia.fagarasan@riken.jp
lab head
Midy Wu
contact affiliationRIKEN
contact emailwyb0828@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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