PXD028403
PXD028403 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | B cell-derived GABA elicits IL-10+ macrophages and limits anti-tumor immunity |
Description | Small, soluble metabolites are not only essential intermediates in intracellular biochemical processes, but can also influence neighboring cells when released into the extracellular milieu. Here, we identify the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages which secrete IL-10 and inhibit CD8+ T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA generating enzyme GAD67 enhances anti-tumor responses. Our study reveals that in addition to cytokines and membrane proteins, small metabolites derived from B lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-15 |
AnnouncementXML | Submission_2021-12-02_07:16:28.844.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Midy Wu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-09 09:00:34 | ID requested | |
1 | 2021-11-15 03:47:39 | announced | |
⏵ 2 | 2021-12-02 07:16:29 | announced | 2021-12-02: Updated publication reference for PubMed record(s): 34732892. |
Publication List
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S, limit anti-tumour immunity. Nature, 599(7885):471-476(2021) [pubmed] |
Keyword List
submitter keyword: GABA, B cells, macrophages, anti-tumor immunity |
Contact List
Sidonia Fagarasan | |
---|---|
contact affiliation | Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan |
contact email | sidonia.fagarasan@riken.jp |
lab head | |
Midy Wu | |
contact affiliation | RIKEN |
contact email | wyb0828@gmail.com |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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