PXD028382

PXD028382 is an original dataset announced via ProteomeXchange.

Title	Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts
Description	The modification of peptides and proteins has emerged as a powerful means to efficiently prepare high value bioconjugates for a range of applications in chemical biology and for the development of next-generation therapeutics. Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates. The power of this new platform is showcased through the late-stage modification of the affibody zEGFR and the histone protein H2A.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_13:42:24.814.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mark Larance
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:34:09	ID requested
⏵ 1	2024-10-07 13:42:25	announced

Byrne SA, Bedding MJ, Corcilius L, Ford DJ, Zhong Y, Franck C, Larance M, Mackay JP, Payne RJ, Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts. Chem Sci, 12(42):14159-14166(2021) [pubmed]

10.1039/d1sc03127a;

submitter keyword: H2A, synthesis, modification

Mark Larance
contact affiliation	University of Sydney
contact email	mark.larance@sydney.edu.au
lab head
Mark Larance
contact affiliation	The University of Sydney
contact email	mark.larance@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD028382

PRIDE project URI

• PRIDE
  1. PXD028382
     1. Label: PRIDE project
     2. Name: Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts