PXD028378

PXD028378 is an original dataset announced via ProteomeXchange.

Title	Hypothyroidism symptoms in LT4-euthyroid thyroidectomized patients reflect an alteration of the serum proteome
Description	In patients undergoing thyroidectomy one of the goals of post-surgical follow-up is the correct maintenance of thyroid hormone (TH) levels by replacement therapy with levo-thyroxine (LT4). Nevertheless, some patients complain of symptoms of hypothyroidism (memory loss, weight gain, fatigue, depression, and reduced quality of life) despite values of thyroid hormones get the physiological range. Since this recurrent issue, we aim to compare serum proteomic profiles of LT4-euthyroid thyroidectomized patients with stable or reduced post-operative quality of life. Proteomic analysis highlights a different protein profile in serum of patients with reduced quality of life compared to the other although both resulted euthyroid. Differential proteins are involved in coagulation processes, complement system activation and in lipoprotein particles remodeling, that together lead to a pro-inflammatory response. Moreover, a particular protein isoform pattern of apolipoprotein A1 and alpha 1 antitrypsin, was also detected. This study suggests that LT4 replacement therapy might restore euthyroid conditions in thyroidectomized patients but in some cases without re-establish body tissues euthyroidism. This condition is reflected by the serum protein profile that shows a behavior similar to overt hypothyroidism.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_09:07:07.228.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enxhi Shaba
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ultraflex

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:33:52	ID requested
⏵ 1	2022-05-25 09:07:08	announced

Landi C, Cantara S, Shaba E, Vantaggiato L, Marzocchi C, Maino F, Bombardieri A, Carleo A, Di Giuseppe F, Angelucci S, Bini L, Castagna MG, Alteration of Serum Proteome in Levo-Thyroxine-Euthyroid Thyroidectomized Patients. J Clin Med, 11(6):(2022) [pubmed]

submitter keyword: Proteomics, hypothyroidism, reduced FT3, LT4, quality of life

Luca Bini
contact affiliation	Dept. Life Sciences, Functional Proteomics Lab, Siena University, Italy.
contact email	luca.bini@unisi.it
lab head
Enxhi Shaba
contact affiliation	Functional Proteomics Lab. Life Sciences Department, University of Siena
contact email	enxhishaba@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD028378

PRIDE project URI

• PRIDE
  1. PXD028378
     1. Label: PRIDE project
     2. Name: Hypothyroidism symptoms in LT4-euthyroid thyroidectomized patients reflect an alteration of the serum proteome