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PXD028368

PXD028368 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProfiling of IgG N-glycome in gastric cancer by MALDI-TOF-MS
DescriptionBackground: Alterations in IgG glycosylation have been observed in many inflammatory activities and diseases progression, uncovering IgG glycome contributes to deciphering the molecular mechanism of human diseases. Gastric cancer (GC) associated IgG glycosylation was rarely investigated.Methods: We comprehensively characterized IgG N-glycome profile in GC by high-throughput orthogonal mass spectrometry assay, and analyzed the difference of glycosylation between controls and GC patients through multiple statistical tools. Bioinformatics analysis was performed to study the candidate glycogens and their biological functions involved in GC. Results: GC associates with decrease in galactosylation and sialylation of IgG, and increase in bisection and agalactosylation of IgG.Bioinformatics analysis verified the differential expression of significantly changed IgG glycan associated glycogens, indicating the crucial role of IgG glycosylation in the pathogenesis of GC.Conclusions: This study demonstrates the potential diagnostic merits of specific IgG glycans for early detection of GC, as well as revealing molecular mechanism in the development of this cancer.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_08:48:25.325.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSi Liu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrument4800 Proteomics Analyzer
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-09 08:29:47ID requested
12025-05-06 08:48:26announced
Publication List
10.1186/s12885-025-13616-z;
Xu T, Huang J, Lin J, Liu Y, Wang Y, Shen W, He J, Chen S, Zhu X, Que Y, Hu M, Chen Y, Cheng L, He H, Liu X, Liu S, Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression. BMC Cancer, 25(1):217(2025) [pubmed]
Keyword List
submitter keyword: Human serum, IgG, gastric cancer, N-glycome, MALDI-MS
Contact List
Si Liu
contact affiliationDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, N0. 1037 Luoyudong Road, Hongshan District, Wuhan 430074
contact emailxliu@mail.hust.edu.cn
lab head
Si Liu
contact affiliationHuazhong University of Science and Technology
contact emailsiliu2019@163.com
dataset submitter
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Dataset FTP location
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