PXD028356

PXD028356 is an original dataset announced via ProteomeXchange.

Title	Rat DRG CIPN versus Vehicle-treatment_DIA-MS
Description	Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of cancer treatment, often leading to cessation of therapy due to lack of adequate treatment options. In the peripheral nervous system the chemotherapeutic agent paclitaxel impairs mitochondrial function and induces vast changes in gene expression. However, changes at the protein level remain so far unexplored. Here we used an unbiased approach of quantitative proteome profiling in a clinically-relevant rat model of paclitaxel-induced peripheral neuropathy. We analysed two critical timepoints: (1) day 7, equivalent to 1 day after cessation of paclitaxel treatment, prior to neuropathy development; (2) approximately 4 weeks after paclitaxel initiation, when neuropathy has developed.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:06.597.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christin Kappert
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:28:40	ID requested
1	2022-03-24 04:32:40	announced
2	2022-04-07 08:48:19	announced	2022-04-07: Updated project metadata.
⏵ 3	2023-11-14 08:55:07	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: rat, DIA-MS, DRG-Proteome, CIPN, HF-X

Manuela Schmidt
contact affiliation	Systems Biology of Pain Head of the Division of Pharmacology & Toxicology Department of Pharmaceutical Sciences University of Vienna, Austria
contact email	manuela_schmidt@univie.ac.at
lab head
Christin Kappert
contact affiliation	Max Planck Institute of Experimental Medicine
contact email	kappert@em.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD028356

PRIDE project URI

• PRIDE
  1. PXD028356
     1. Label: PRIDE project
     2. Name: Rat DRG CIPN versus Vehicle-treatment_DIA-MS