PXD028338

PXD028338 is an original dataset announced via ProteomeXchange.

Title	Comparative analysis of gut EVs from mice on high and low fat diet
Description	Currently, it is an open question how gut senses metabolic alterations and whether this is transmitted to other tissues via EVs. Here, we observed that protein packaging in gut derived EVs (GDE) from a diet induced-prediabetic mouse mode, specifically small intestine, is increased in prediabetes. Proteins related to lipid metabolism and to oxidative stress management were more abundant in prediabetic GDE compared to healthy controls. Low-fat diet: A1 to A3 high-fat diet: A4 to A6
HostingRepository	PRIDE
AnnounceDate	2022-04-13
AnnouncementXML	Submission_2022-04-13_03:31:27.374.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rune Matthiesen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:27:07	ID requested
⏵ 1	2022-04-13 03:31:30	announced

Ferreira I, Machado de Oliveira R, Carvalho AS, Teshima A, Beck HC, Matthiesen R, Costa-Silva B, Macedo MP, Messages from the Small Intestine Carried by Extracellular Vesicles in Prediabetes: A Proteomic Portrait. J Proteome Res, 21(4):910-920(2022) [pubmed]

submitter keyword: mice, gut, LC-MS, Type 2 diabetes, Lipids

Diet

Rune Matthiesen
contact affiliation	Computational and Experimental Biology Group NOVA MEDICAL SCHOOL / FACULDADE DE CIÊNCIAS MÉDICAS UNIVERSIDADE NOVA DE LISBOA Rua Câmara Pestana, 6-6A | 1150-082 Lisboa Portugal E-mail: rune.matthiesen@nms.unl.pt | www.nms.unl.pt
contact email	runem2009@gmail.com
lab head
Rune Matthiesen
contact affiliation	Computational and Experimental Biology Group, CEDOC NOVA MEDICAL SCHOOL / FACULDADE DE CIÊNCIAS MÉDICAS UNIVERSIDADE NOVA DE LISBOA Rua Câmara Pestana, 6-6A | 1150-082 Lisboa Portugal
contact email	runem2009@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD028338

PRIDE project URI

• PRIDE
  1. PXD028338
     1. Label: PRIDE project
     2. Name: Comparative analysis of gut EVs from mice on high and low fat diet