PXD028317

PXD028317 is an original dataset announced via ProteomeXchange.

Title	Proteomic detection of mouse liver
Description	This study aimed to investigate the mechanism of SYT on lipid metabolism and insulin sensitivity in high-fat diet (HFD)-induced obese mice by means of combining lipidomics and proteomics. The obese mice models were developed via HFD feeding for 20 consecutive weeks. Mice in the treatment group were given metformin and SYT respectively, and the effects of SYT on body weight, blood glucose, insulin sensitivity, fat accumulation in the organs, and pathological changes in the liver were monitored. Lipid metabolism was examined by lipidomics. Further determination of signaling pathways was detected by proteomics. The biological contributions of the compounds detected in SYT's chemical fingerprint were predicted by network pharmacology. Overall, our study provides supportive evidence for the mechanism of SYT's therapeutic effect on dysregulated lipid metabolism in diabesity.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_04:28:05.133.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yanzhen Zhao
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:21:52	ID requested
⏵ 1	2022-02-16 04:28:05	announced

Yao M, Li L, Huang M, Tan Y, Shang Y, Meng X, Pang Y, Xu H, Zhao X, Lei W, Chang Y, Wang Y, Zhang D, Zhang B, Li Y, Sanye Tablet Ameliorates Insulin Resistance and Dysregulated Lipid Metabolism in High-Fat Diet-Induced Obese Mice. Front Pharmacol, 12():713750(2021) [pubmed]

submitter keyword: Mouse, Liver

Lin Li
contact affiliation	Tianjin University of Traditional Chinese Medicine
contact email	einnie_li27@sina.com
lab head
yanzhen Zhao
contact affiliation	shanghai
contact email	449096780@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD028317

PRIDE project URI

• PRIDE
  1. PXD028317
     1. Label: PRIDE project
     2. Name: Proteomic detection of mouse liver