PXD028312

PXD028312 is an original dataset announced via ProteomeXchange.

Title	Fox serum proteomics analysis suggests host-specific responses to Angiostrongylus vasorum infection
Description	Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from eight experimentally infected foxes before and after inoculation (day 0, 35, 84, 154) were subjected to quantitative proteomic analysis and compared to available data from dogs. The number of differentially expressed proteins compared to uninfected baseline increased with chronicity of the infection. Bone marrow proteoglycan, chitinase 3-like protein 1 and pulmonary surfactant-associated protein B were among strongly upregulated proteins. Several proteins involved in coagulation were downregulated. Enriched pathways obtained from both up- and downregulated proteins included among others ‘platelet degranulation‘ and ‘haemostasis’, and indicated both activation and suppression of coagulation. Qualitative comparison to dog data suggests some parallel serum proteomic alterations. The comparison, however, highlights that foxes have a more balanced immunopathological response to A. vasorum infection compared to dogs, facilitating parasite survival in foxes. Our findings imply that foxes may cope better with an A. vasorum infection and that A. vasorum is likely more adapted to foxes as compared to dogs, explaining the relevant role of foxes as wildlife reservoir.
HostingRepository	PRIDE
AnnounceDate	2021-11-25
AnnouncementXML	Submission_2021-11-25_08:34:49.894.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nina Gillis
SpeciesList	scientific name: Vulpes vulpes; NCBI TaxID: 9627;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:21:20	ID requested
⏵ 1	2021-11-25 08:34:50	announced

Dataset with its publication pending

submitter keyword: Angiostrongylus vasorum, proteomics, fox, Vulpes vulpes, immune response, coagulation

Manuela Schnyder
contact affiliation	Institute of Parasitology Vetsuisse Faculty University of Zurich Winterthurerstrasse 266a 8057 Zürich Switzerland
contact email	Manuela.Schnyder@uzh.ch
lab head
Nina Gillis
contact affiliation	Institute of Parasitology, University of Zurich
contact email	nina.gillis@uzh.ch
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD028312
     1. Label: PRIDE project
     2. Name: Fox serum proteomics analysis suggests host-specific responses to Angiostrongylus vasorum infection