PXD028227
PXD028227 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrating SWATH-MS Proteomics and Transcriptome Analysis Identifies Three DEGs as Biomarkers for Proliferative Diabetic Retinopathy Running heading-Three Biomarkers for PDR |
| Description | Although management of risk factors, including hyperglycemia, hyperlipidemia, and hypertension, have been shown to ameliorate diabetes-induced vision loss, effective noninvasive medical therapies for the prevention of PDR remain an unmet clinical need. We intended to find differentially expressed proteins that play crucial roles in proliferative diabetic retinopathy. We provide a novel strategy for biomarker screening, combining recent MS techniques with public database analysis, and identified plasma FCGR3A, DPEP2 and ADGRF5 as potential biomarkers for patients with PDR. Identifying the key molecules of the disease is essential for the development of new therapeutic molecules and new uses of existing drugs. |
| HostingRepository | iProX |
| AnnounceDate | 2021-09-09 |
| AnnouncementXML | Submission_2022-11-10_19:06:56.179.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiwei Xu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-09-08 20:27:52 | ID requested | |
| ⏵ 1 | 2022-11-10 19:06:57 | announced |
Publication List
| Wu H, Wang D, Zheng Q, Xu Z, Integrating SWATH-MS proteomics and transcriptome analysis to preliminarily identify three DEGs as biomarkers for proliferative diabetic retinopathy. Proteomics Clin Appl, 16(1):e2100016(2022) [pubmed] |
Keyword List
| submitter keyword: proliferative diabetic retinopathy, Proteomics, SWATH-MS, GEO dataset |
Contact List
| Dongguo Wang | |
|---|---|
| contact affiliation | Taizhou Municipal Hospital Affiliated with Taizhou University |
| contact email | wdgtzs@163.com |
| lab head | |
| Zhiwei Xu | |
| contact affiliation | Taizhou Municipal Hospital Affiliated with Taizhou University |
| contact email | xzhwwork123@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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