PXD028211

PXD028211 is an original dataset announced via ProteomeXchange.

Title	Proteomics reveals the ribosome signaling pathway promoting prostate cancer progression and correlating with poor prognosis
Description	Through digital rectal examinations and routine prostate-specific antigen (PSA) screening, early treatment of prostate cancer has become possible. However, prostate cancer is a complex and heterogeneous disease. In many patients, cancer cells can invade adjacent tissues and metastasize to other tissues, resulting in difficultly to cure. For the treatment of primary and metastatic prostate cancer, a significant problem is how to improve its survival time. Here, we collect 7 untreated primary and metastatic prostate cancer and 6 benign prostate hyperplasia samples under ultrasound guidance by experienced radiologists using the 18-G needle. Through mass spectrometry, we have completely depicted the protein atlas of primary and metastatic prostate cancer and benign prostate hyperplasia. Through bioinformatics analysis, experimental verification, and combined clinical data, we discover that the ribosome signaling pathway promotes the progression of prostate cancer and is associated with a poor prognosis. Among them, Mrpl1, Mrpl4, and Mrpl16 may be biomolecular markers for diagnosis and prognosis.
HostingRepository	iProX
AnnounceDate	2021-09-05
AnnouncementXML	Submission_2024-03-18_19:05:34.649.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiangbei Yuan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-05 20:58:52	ID requested
1	2023-10-31 19:05:13	announced
⏵ 2	2024-03-18 19:05:35	announced	2024-03-19: Update information.

Fu Q, Luo L, Hong R, Zhou H, Xu X, Feng Y, Huang K, Wan Y, Li Y, Gong J, Le X, Liu X, Wang N, Yuan J, Li F, Radiogenomic analysis of ultrasound phenotypic features coupled to proteomes predicts metastatic risk in primary prostate cancer. BMC Cancer, 24(1):290(2024) [pubmed]

submitter keyword: Quantitative proteomics, Ribosome signaling pathway, Prostate cancer, Mrpl16, Mrpl4, Mrpl1, Prognosis

Jiangbei Yuan
contact affiliation	Peking University Shenzhen Hospital
contact email	yuanjiangbei@163.com
lab head
Jiangbei Yuan
contact affiliation	Peking University Shenzhen Hospital
contact email	yuanjiangbei@163.com
dataset submitter

iProX dataset URI