PXD028194

PXD028194 is an original dataset announced via ProteomeXchange.

Title	Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis
Description	Mouse of SiO2 group were instilled with silica suspension, and mouse of control group were instilled with NS. The mouse mouse were raised for 56 d, and then the ECM was harvest. We found out the main protein deposited in fabrotic lung ECM. By spatial transcriptomics, we analyzed the distribution pattern of transcripts in space. Using sc-RNA sequencing, we investigated the cell resource of IgA.
HostingRepository	iProX
AnnounceDate	2021-08-31
AnnouncementXML	Submission_2022-11-11_01:19:50.570.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mengling Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-01 07:01:34	ID requested
⏵ 1	2022-11-11 01:19:51	announced

Yin J, Wang J, Zhang X, Liao Y, Luo W, Wang S, Ding J, Huang J, Chen M, Wang W, Fang S, Chao J, A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation. Cell Biosci, 12(1):21(2022) [pubmed]

submitter keyword: lung ECM, fibrosis, sc-RNA sequencing, spatial transcriptomics, proteome, IgA

Jie Chao
contact affiliation	Department of Physiology, School of Medicine, Southeast University
contact email	chaojie@seu.edu.cn
lab head
Mengling Chen
contact affiliation	Department of Physiology, School of Medicine, Southeast University
contact email	83046632@qq.com
dataset submitter

iProX dataset URI