PXD028190
PXD028190 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes and Can be Partially Reversed by Antiviral Therapy |
Description | Global temporal quantitative proteomic and transcriptomic analysis using long-term hepatitis B virus (HBV)-infected primary human hepatocytes uncovered extensive remodeling of host proteome and transcriptome, and revealed cytopathic effects of long-term viral replication. Metabolic-, complement-, cytoskeleton-, mitochondrial- and oxidation-related pathways were modulated at transcriptional or post-transcriptional levels, which could be partially rescued by early rather than late nucleot(s)ide analogs (NAs) therapy. Overexpression screening identified a series of pro- or anti- HBV host factors. These data have deepened the understanding of the mechanisms of viral pathogenesis and HBV-host interactions in hepatocytes, with implications for therapeutic intervention. |
HostingRepository | iProX |
AnnounceDate | 2021-08-31 |
AnnouncementXML | Submission_2022-10-21_02:42:00.035.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wenjing Zai |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-01 04:56:13 | ID requested | |
1 | 2021-09-01 04:56:25 | announced | |
⏵ 2 | 2022-10-21 02:42:01 | announced | 2022-10-21: Update publication information. |
Publication List
Zai W, Hu K, Ye J, Ding J, Huang C, Li Y, Fang Z, Wu M, Wang C, Chen J, Yuan Z, Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy. Microbiol Spectr, 10(1):e0132821(2022) [pubmed] |
Keyword List
submitter keyword: long-term HBV infection, quantitative temporal proteomics, cytopathic effects, nucleot(s)ide analogues, viral-host interaction |
Contact List
Zhenghong Yuan | |
---|---|
contact affiliation | Fudan University |
contact email | zhyuan@shmu.edu.cn |
lab head | |
Wenjing Zai | |
contact affiliation | Fudan University |
contact email | zaiwjing@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |