PXD028182
PXD028182 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of saliva of Haemaphysalis longicornis during half blood |
Description | Tick saliva, an essential chemical secretion of the tick salivary gland, is indispensable for tick survival owing to the physiological influence it exerts on the host defense mechanisms via the instrumentality of its cocktail of pharmacologically active molecules (proteins and peptides).Here, we performed a phosphoproteomic analysis of Haemaphysalis longicornis tick saliva via LC-MS/MS. A total of 262 phosphorylated tick saliva proteins were identified, and were subjected to functional annotation/enrichment analysis. Cellular and metabolic process terms accounted for the largest proportion of the saliva proteins, with the participation of these proteins in vital intracellular and extracellular transport-oriented processes such as vesicle-mediated transport, exocytic process, cell adhesion, and movement of cell or subcellular component. “Endocytosis”, “Protein processing in endoplasmic reticulum”, and “Purine metabolism” were the most significantly enriched pathways. The knockdown (RNAi) of Tudor domain-containing protein (TCP), actin depolymerizing factors (ADF), programmed cell death protein (PD), and serine/threonine-protein kinase (SPK) resulted in the dissociation of collagen fibers and pilosebaceous unit, increased inflammatory infiltrates/granulocytes (possibly heterophyles), and the depletion of the epithelium. |
HostingRepository | iProX |
AnnounceDate | 2021-12-14 |
AnnouncementXML | Submission_2022-10-21_02:40:13.783.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ningmei Wang |
SpeciesList | scientific name: Haemaphysalis longicornis; NCBI TaxID: 44386; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-08-31 02:38:05 | ID requested | |
1 | 2021-08-31 02:40:03 | announced | |
⏵ 2 | 2022-10-21 02:40:14 | announced | 2022-10-21: Update publication information. |
Publication List
Agwunobi DO, Wang N, Huang L, Zhang Y, Chang G, Wang K, Li M, Wang H, Liu J, Saliva Reveals the Influential Contributions of Phosphoproteins to Blood-Feeding Success. Front Cell Infect Microbiol, 11():769026(2021) [pubmed] |
Keyword List
submitter keyword: Haemaphysalis longicornis,saliva |
Contact List
Hui Wang | |
---|---|
contact affiliation | Hebei Normal University |
contact email | whui1981@163.com |
lab head | |
Ningmei Wang | |
contact affiliation | Hebei Normal University |
contact email | 767247571@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |