PXD028157

PXD028157 is an original dataset announced via ProteomeXchange.

Title	Proteomics quantification of striatal fraction from DAT-KO and WT rats
Description	The study aimed to find out quantitative changes at the protein level in the total membrane fraction enriched in synaptosomes and mitochondria upon the absence of the dopamine transporter in rat brain. Therefore, the brain of male rats (Wister Han) DAT-wildtype and DAT-knockout animals, were dissected and the striatum was used for the enrichment of the synaptic and mitochondrial membrane fraction. The proteins of the total membrane fraction were further tryptically digested and analysed via label-free LC-MSMS.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_04:03:36.603.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carina Mueller
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-26 04:30:29	ID requested
⏵ 1	2022-05-19 04:03:37	announced

Savchenko A, M, ü, ller C, Lubec J, Leo D, Korz V, Afjehi-Sadat L, Malikovic J, Sialana FJ, Lubec G, Sukhanov I, The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes. Front Psychiatry, 13():799433(2022) [pubmed]

submitter keyword: Rat, Brain, Striatum, Dopamine transporter, DAT, DAT-KO, knockout, LC-MSMS, Proteomics

Gert Lubec
contact affiliation	Proteomics Programme, Paracelsus Medical University, Salzburg, Austria
contact email	gert.lubec@lubeclab.com
lab head
Carina Mueller
contact affiliation	University of Vienna
contact email	carina.mueller@univie.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD028157

PRIDE project URI

• PRIDE
  1. PXD028157
     1. Label: PRIDE project
     2. Name: Proteomics quantification of striatal fraction from DAT-KO and WT rats