PXD028151 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Regulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses |
Description | p38 and JNK are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators GIGYF1 and 2 by p38-dependent MK2 phosphorylation and 14-3-3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-22 |
AnnouncementXML | Submission_2021-09-21_22:47:16.112.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ana Martinez-Val |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-26 04:06:44 | ID requested | |
1 | 2021-09-13 07:56:46 | announced | |
⏵ 2 | 2021-09-21 22:47:17 | announced | 2021-09-22: Updated project metadata. |
Publication List
Nordgaard C, Tollenaere MAX, Val AMD, Bekker-Jensen DB, Blasius M, Olsen JV, Bekker-Jensen S, Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses. Int J Mol Sci, 22(17):(2021) [pubmed] |
10.3390/IJMS22179595; |
Keyword List
submitter keyword: p38, JNK,Golgi |
Contact List
Jesper V. Olsen |
contact affiliation | Vice Director, Professor Novo Nordisk Foundation Center for Protein Research Proteomics Program University of Copenhagen |
contact email | jesper.olsen@cpr.ku.dk |
lab head | |
Ana Martinez-Val |
contact affiliation | Novo Nordisk Foundation Center for Protein Research |
contact email | ana.mdval@cpr.ku.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028151
- Label: PRIDE project
- Name: Regulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses