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PXD028151

PXD028151 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRegulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses
Descriptionp38 and JNK are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators GIGYF1 and 2 by p38-dependent MK2 phosphorylation and 14-3-3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications.
HostingRepositoryPRIDE
AnnounceDate2021-09-22
AnnouncementXMLSubmission_2021-09-21_22:47:16.112.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAna Martinez-Val
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-26 04:06:44ID requested
12021-09-13 07:56:46announced
22021-09-21 22:47:17announced2021-09-22: Updated project metadata.
Publication List
Nordgaard C, Tollenaere MAX, Val AMD, Bekker-Jensen DB, Blasius M, Olsen JV, Bekker-Jensen S, Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses. Int J Mol Sci, 22(17):(2021) [pubmed]
10.3390/IJMS22179595;
Keyword List
submitter keyword: p38, JNK,Golgi
Contact List
Jesper V. Olsen
contact affiliationVice Director, Professor Novo Nordisk Foundation Center for Protein Research Proteomics Program University of Copenhagen
contact emailjesper.olsen@cpr.ku.dk
lab head
Ana Martinez-Val
contact affiliationNovo Nordisk Foundation Center for Protein Research
contact emailana.mdval@cpr.ku.dk
dataset submitter
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Dataset FTP location
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