PXD028102
PXD028102 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome-Centric Cross-Omics Characterization and Integrated Network Analyses of Triple-Negative Breast Cancer |
| Description | We undertook the first systemic proteomic study of a 90-case cohort of triple-negative breast cancer (TNBC) with a panoramic proteome view in quantification, phosphorylation, and DNA-binding capacity. Four integrative subtypes (iP-1-4) were stratified based on the proteome quantification profile and phosphoproteome, each of which exhibited distinct molecular, pathway, and network characteristics. Integrated network analyses of 3 proteomic datasets, together with those of genome and transcriptome from the same cohort, revealed holistic views of altered cellular processes and their regulation by/of upstream/downstream molecules, pathways and functional communities in the background of an integrated molecular network. |
| HostingRepository | iProX |
| AnnounceDate | 2021-08-24 |
| AnnouncementXML | Submission_2023-10-12_23:32:15.746.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tianqi Gong |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Fusion; Orbitrap Fusion Lumos; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-08-24 21:08:40 | ID requested | |
| ⏵ 1 | 2023-10-12 23:32:16 | announced |
Publication List
| Gong TQ, Jiang YZ, Shao C, Peng WT, Liu MW, Li DQ, Zhang BY, Du P, Huang Y, Li FF, Li MY, Han ZL, Jin X, Ma D, Xiao Y, Yang PY, Qin J, Shao ZM, Zhu W, Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer. Cell Rep, 38(9):110460(2022) [pubmed] |
Keyword List
| submitter keyword: Multi-omics integration, proteome, network analysis, TNBC, drug target |
Contact List
| Weimin Zhu | |
|---|---|
| contact affiliation | Chinese Academy of Sciences |
| contact email | weimindba@yahoo.ca |
| lab head | |
| Tianqi Gong | |
| contact affiliation | Fudan University |
| contact email | 16111510013@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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