PXD028081

PXD028081 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of extracellular vesicles from thyroid tumours
Description	Extracellular vesicles (EVs) participate in cell-stroma crosstalk within tumor microenvironment (TME) and Fb are key elements that contribute to tumor promotion. In thyroid cancer, the most prevalent endocrine malignancy, the relevance of Fb in the TME and EVs is beginning to be deciphered. Using an in vitro model of tumor-stroma crosstalk, we performed the comparative proteomic analysis of EVs secreted in tumoral- and non-tumoral milieu to describe EV-functionality and examine their possible role in thyroid tumor progression-related events. Tumor (TPC-1, 8505c) or non-tumor (NThyOri) thyroid cells were co-cultured with human fibroblasts (Fb). EVs, obtained by ultracentrifugation of conditioned media (CMs), were characterized by mass-spectrometry.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:53:52.553.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD028081
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-24 02:31:10	ID requested
1	2022-08-02 03:00:35	announced
⏵ 2	2023-11-14 08:53:53	announced	2023-11-14: Updated project metadata.

10.6019/PXD028081;

submitter keyword: thyroid tumour,Extracellular vesicles, tumor-stroma crosstalk, fibroblasts

Felix Elortza
contact affiliation	Proteomics Service CIC bioGUNE, Build. 800 Bizkaia Tech. Derio 48160 Spain
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD028081

PRIDE project URI

• PRIDE
  1. PXD028081
     1. Label: PRIDE project
     2. Name: Proteomics analysis of extracellular vesicles from thyroid tumours