PXD028060

PXD028060 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Description	Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:40.310.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD028060
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sumit Bhutada
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-23 06:36:12	ID requested
1	2023-11-03 09:48:16	announced
⏵ 2	2023-11-14 09:13:47	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD028060;
Bhutada S, Li L, Willard B, Muschler G, Piuzzi N, Apte SS, Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1. Osteoarthritis Cartilage, 30(8):1091-1102(2022) [pubmed]

10.6019/PXD028060;

Bhutada S, Li L, Willard B, Muschler G, Piuzzi N, Apte SS, Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1. Osteoarthritis Cartilage, 30(8):1091-1102(2022) [pubmed]

Keyword List

submitter keyword: Cartilage, Serine Protease, Osteoarthritis, HtrA1

submitter keyword: Cartilage, Serine Protease, Osteoarthritis, HtrA1

Contact List

Suneel Apte
contact affiliation	Biomedical Engineering, Lerner Research Institute, Cleveland, USA.
contact email	aptes@ccf.org
lab head
Sumit Bhutada
contact affiliation	Cleveland Clinic
contact email	bhutads@ccf.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD028060
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD028060

PRIDE project URI

Repository Record List

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