PXD028055

PXD028055 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A Multi-omics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem Cell-derived Cardiomyocytes
Description	Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show immense promise for patient-specific disease modeling, cardiotoxicity screening, and regenerative therapy development. However, hPSC-CMs in culture have not recapitulated the structural or functional properties of adult CMs in vivo thus far. To gain global insight into hPSC-CM biology, we established a multi-omics method for analyzing the hPSC-CM metabolome and proteome from the same cell culture, creating multi-dimensional profiles of hPSC-CMs. Specifically, we developed a sequential extraction to capture metabolites and proteins from the same hPSC-CM monolayer cultures, and analyzed these extracts using high-resolution mass spectrometry (MS).
HostingRepository	MassIVE
AnnounceDate	2021-08-22
AnnouncementXML	Submission_2021-08-22_20:13:49.002.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elizabeth Bayne
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl; Homocysteic_acid; Carbamidomethyl
Instrument	timsTOF Pro; solariX

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-22 18:59:43	ID requested
⏵ 1	2021-08-22 20:13:49	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Multi-Omics

submitter keyword: Multi-Omics

Contact List

Ying Ge
contact affiliation	University of Wisconsin-Madison
contact email	ge2@wisc.edu
lab head
Elizabeth Bayne
contact affiliation	University of Wisconsin - Madison
contact email	ebayne@wisc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088010/