PXD028028

PXD028028 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomic Responses of Distal TORC1 Target Kinases Reveal Discrete and Convergent Mechanisms that Orchestrate the Quiescence Program in Yeast
Description	TORC1 inhibition following nutrient limitation unlocks various distally controlled kinases (e.g., Atg1, Gcn2, Slt2/Mpk1, Npr1, Rim15, and Yak1), which cooperate through poorly defined circuits to orchestrate the quiescence program. To better define the signaling landscape of the latter kinases, we used in vivo quantitative phosphoproteomics. While pinpointing known and numerous hitherto uncharted Slt2/Mpk1, Npr1, Rim15, and Yak1 effectors, our study reveals insight into the architecture of the distally controlled TORC1 kinase network.
HostingRepository	PRIDE
AnnounceDate	2022-02-08
AnnouncementXML	Submission_2022-02-08_01:55:07.395.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joern Dengjel
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-19 03:55:49	ID requested
⏵ 1	2022-02-08 01:55:08	announced

Dokl, á, dal L, Stumpe M, Hu Z, Jaquenoud M, Dengjel J, De Virgilio C, Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep, 37(13):110149(2021) [pubmed]

submitter keyword: yeast, kinase, phosphoproteomics, SILAC

Joern Dengjel
contact affiliation	Dr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch
contact email	joern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliation	University of Fribourg
contact email	joern.dengjel@medizin.uni-freiburg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD028028

PRIDE project URI

• PRIDE
  1. PXD028028
     1. Label: PRIDE project
     2. Name: Phosphoproteomic Responses of Distal TORC1 Target Kinases Reveal Discrete and Convergent Mechanisms that Orchestrate the Quiescence Program in Yeast