PXD027999

PXD027999 is an original dataset announced via ProteomeXchange.

Title	Degradation of misfolded HLA B*2704 (associated with disease) involves UPR, autophagy and aggresomes whereas degradation of HLA B*2709 (non-associated with disease) involves the endosomal-lysosomal pathway
Description	Ankylosing spondylitis (AS) belongs to a group of diseases, called spondyloarthropathies (SpA), which are strongly associated with the genetic marker, HLA-B27. AS is characterized by inflammation of joints, and primarily affects the spine. Over 200 subtypes of HLA B27 are known, owing to high polymorphism. Some are strongly associated with disease (e.g., B*2704) whereas others are rarely associated (e.g., B*2709). Misfolding of HLA-B27 molecules [as dimers, or as high molecular weight (HMW) oligomers] is one of several hypotheses proposed. Our group has previously established the existence of HMW species of HLA-B27 in AS patients. Still, very little is known about the mechanisms underlying differences in pathogenic outcomes of different HLA-B27 subtypes. We conducted a proteomics-based evaluation of the differential disease association of HLA B*2704 and B*2709, using stable transfectants of genes encoding the two proteins.
HostingRepository	PRIDE
AnnounceDate	2021-12-23
AnnouncementXML	Submission_2021-12-23_03:26:23.239.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AMIT THAKUR
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-18 02:30:56	ID requested
⏵ 1	2021-12-23 03:26:23	announced

Dataset with its publication pending

submitter keyword: HLA-B27

disease association

subtypes

Manni Luthra-Guptasarma
contact affiliation	Department of Immunopathology, PGIMER, Chandigarh
contact email	mguptasarma@yahoo.com
lab head
AMIT THAKUR
contact affiliation	PGIMER
contact email	thakuramit681@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027999
     1. Label: PRIDE project
     2. Name: Degradation of misfolded HLA B*2704 (associated with disease) involves UPR, autophagy and aggresomes whereas degradation of HLA B*2709 (non-associated with disease) involves the endosomal-lysosomal pathway