PXD027997

PXD027997 is an original dataset announced via ProteomeXchange.

Title	Systemic effects of hemorrhagic snake venom metalloproteinases: untargeted peptidomics to explore the pathodegradome of plasma proteins
Description	In this study we investigated the proteolysis of human plasma proteins by HF3, an hemorrhagic metalloproteinase from B. jararaca venom. For this purpose, approaches for the depletion of the most abundant proteins and for the enrichment of low abundant proteins of human plasma were used to minimize the dynamic range of protein concentration, in order to assess the proteolytic activity of HF3 on a wide spectrum of proteins, and to detect the degradation products by mass spectrometry by untargeted peptidomics.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_06:17:10.200.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alison Chaves
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-17 23:59:45	ID requested
⏵ 1	2022-02-17 06:17:10	announced

Bertholim L, Chaves AFA, Oliveira AK, Menezes MC, Asega AF, Tashima AK, Zelanis A, Serrano SMT, Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins. Toxins (Basel), 13(11):(2021) [pubmed]

submitter keyword: Bothrops

snake venom

Hemorrhagic factor 3 (HF3)

human plasma

degradome

Solange Maria de Toledo Serrano
contact affiliation	Laboratório de Toxinologia Aplicada Center of Toxins, Immune-Response and Cell Signaling (CeTICS) Instituto Butantan - Brazil
contact email	solange.serrano@butantan.gov.br
lab head
Alison Chaves
contact affiliation	Instituto Butantan
contact email	alison.chaves@esib.butantan.gov.br
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD027997

PRIDE project URI

• PRIDE
  1. PXD027997
     1. Label: PRIDE project
     2. Name: Systemic effects of hemorrhagic snake venom metalloproteinases: untargeted peptidomics to explore the pathodegradome of plasma proteins