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PXD027974

PXD027974 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of mouse hearts treated with and without 2-deoxy-D-glucose
Description2-deoxy-D-glucose (2DG) is a glucose analog that is established to inhibit glucose metabolism via glycolysis. It has long been recognized as a potential chemical mimetic of calorie restriction, and it also has been shown to have anti-viral effects in infected cells, against among others SARS-CoV-2. This study aimed to determine whether intermittent treatment of mice with 2DG could alter nutrient metabolism in vivo and whether this would produce a proteomic signature of altered glucose metabolism and other cellular pathways, with a view to explaining the anti-viral properties of 2DG. Parallel physiological studies of the heart aimed to relate any proteomic changes to the function and performance of the heart, including assessing whether there were any signs of detrimental effects of 2DG.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:37:08.261.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMikel Azkargorta
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-17 04:46:38ID requested
12022-05-27 11:23:45announced
22024-10-22 05:37:09announced2024-10-22: Updated project metadata.
Publication List
Aiestaran-Zelaia I, S, á, nchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ru, í, z-Cabello J, Holt IJ, 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Sci Rep, 12(1):6890(2022) [pubmed]
10.1038/s41598-022-10168-1;
Keyword List
submitter keyword: heart, differential proteomics,2-deoxy-D-glucose (2DG), nutrient metabolism
Contact List
Felix Elortza
contact affiliationProteomics Platform CIC bioGUNE Bizkaia Tech. Park, Build. 800 Derio 48160 Bizkaia (Spain)
contact emailfelortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliationProteomics Platform CIC bioGUNE
contact emailmazkargorta@cicbiogune.es
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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