PXD027974 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of mouse hearts treated with and without 2-deoxy-D-glucose |
Description | 2-deoxy-D-glucose (2DG) is a glucose analog that is established to inhibit glucose metabolism via glycolysis. It has long been recognized as a potential chemical mimetic of calorie restriction, and it also has been shown to have anti-viral effects in infected cells, against among others SARS-CoV-2. This study aimed to determine whether intermittent treatment of mice with 2DG could alter nutrient metabolism in vivo and whether this would produce a proteomic signature of altered glucose metabolism and other cellular pathways, with a view to explaining the anti-viral properties of 2DG. Parallel physiological studies of the heart aimed to relate any proteomic changes to the function and performance of the heart, including assessing whether there were any signs of detrimental effects of 2DG. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:37:08.261.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mikel Azkargorta |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-17 04:46:38 | ID requested | |
1 | 2022-05-27 11:23:45 | announced | |
⏵ 2 | 2024-10-22 05:37:09 | announced | 2024-10-22: Updated project metadata. |
Publication List
Aiestaran-Zelaia I, S, á, nchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ru, í, z-Cabello J, Holt IJ, 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Sci Rep, 12(1):6890(2022) [pubmed] |
10.1038/s41598-022-10168-1; |
Keyword List
submitter keyword: heart, differential proteomics,2-deoxy-D-glucose (2DG), nutrient metabolism |
Contact List
Felix Elortza |
contact affiliation | Proteomics Platform CIC bioGUNE Bizkaia Tech. Park, Build. 800 Derio 48160 Bizkaia (Spain) |
contact email | felortza@cicbiogune.es |
lab head | |
Mikel Azkargorta |
contact affiliation | Proteomics Platform CIC bioGUNE |
contact email | mazkargorta@cicbiogune.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027974
- Label: PRIDE project
- Name: Proteomic analysis of mouse hearts treated with and without 2-deoxy-D-glucose