PXD027974

PXD027974 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of mouse hearts treated with and without 2-deoxy-D-glucose
Description	2-deoxy-D-glucose (2DG) is a glucose analog that is established to inhibit glucose metabolism via glycolysis. It has long been recognized as a potential chemical mimetic of calorie restriction, and it also has been shown to have anti-viral effects in infected cells, against among others SARS-CoV-2. This study aimed to determine whether intermittent treatment of mice with 2DG could alter nutrient metabolism in vivo and whether this would produce a proteomic signature of altered glucose metabolism and other cellular pathways, with a view to explaining the anti-viral properties of 2DG. Parallel physiological studies of the heart aimed to relate any proteomic changes to the function and performance of the heart, including assessing whether there were any signs of detrimental effects of 2DG.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:37:08.261.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-17 04:46:38	ID requested
1	2022-05-27 11:23:45	announced
⏵ 2	2024-10-22 05:37:09	announced	2024-10-22: Updated project metadata.

Publication List

Aiestaran-Zelaia I, S, á, nchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ru, í, z-Cabello J, Holt IJ, 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Sci Rep, 12(1):6890(2022) [pubmed]
10.1038/s41598-022-10168-1;

Aiestaran-Zelaia I, S, á, nchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ru, í, z-Cabello J, Holt IJ, 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Sci Rep, 12(1):6890(2022) [pubmed]

10.1038/s41598-022-10168-1;

Keyword List

submitter keyword: heart, differential proteomics,2-deoxy-D-glucose (2DG), nutrient metabolism

submitter keyword: heart, differential proteomics,2-deoxy-D-glucose (2DG), nutrient metabolism

Contact List

Felix Elortza
contact affiliation	Proteomics Platform CIC bioGUNE Bizkaia Tech. Park, Build. 800 Derio 48160 Bizkaia (Spain)
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD027974
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD027974

PRIDE project URI

Repository Record List

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