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PXD027972

PXD027972 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Profiling Identifies Novel Diagnostic Biomarkers and Molecular subtypes for Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
DescriptionMucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm resembling type 1 papillary renal cell carcinoma (PRCC) morphologically and immunohistochemically. The accurate diagnosis of MTSCC remains a challenge. Here, by using proteomic profiling, we characterized MTSCC and PRCC to identify diagnostic biomarkers. We found that MTSCC tumor proteome was significantly enriched in B cell-mediated immunity when compared with the proteome of adjacent normal tissues of MTSCC or tumors of PRCC. Importantly, we identified MZB1, VCAN, and SOSTDC1 as diagnostic biomarkers to distinguish MTSCC from PRCC, with an AUC of 0.9839 when combined. MZB1 was inversely correlated with tumor clinical stage and may play an anti-tumor role by activating the complement system. Finally, unsupervised clustering revealed two molecular subtypes of MTSCC, displaying different morphology, expression signatures of oxidative phosphorylation, and aggravation. In summary, our analyses identified a three-protein diagnostic panel and molecular subtypes for MTSCC.
HostingRepositoryPRIDE
AnnounceDate2022-02-11
AnnouncementXMLSubmission_2022-02-11_07:08:17.316.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFen Wang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-17 04:30:53ID requested
12022-02-11 06:55:16announced
22022-02-11 07:08:18announced2022-02-11: Updated publication reference for PubMed record(s): 35043389.
Publication List
Xu H, Li W, Zhu C, Cheng N, Li X, Hao F, Zhu J, Huang L, Wang R, Wang L, Luo Z, Wang F, Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney. J Pathol, 257(1):53-67(2022) [pubmed]
Keyword List
submitter keyword: Kidney, mucinous tubular and spindle cell carcinoma, proteomic, immunohistochemistry
Contact List
Fen Wang
contact affiliationThe First Affiliated Hospital, Sun Yat-Sen University
contact emailwangfen5@mail.sysu.edu.cn
lab head
Fen Wang
contact affiliationThe First Affiliated Hospital, Sun Yat-Sen University
contact emailwangfen5@mail.sysu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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