PXD027959

PXD027959 is an original dataset announced via ProteomeXchange.

Title	Targeted MS based multi-omic analysis of blood plasma from COVID-19 patients to predict survival
Description	Molecular signatures to discriminate patients based on risk of severe disease and mortality from COVID-19 infection are urgently required by the global medical community. Although non-targeted methods are useful for comprehensive ‘omic coverage, targeted MS-based approaches generally provide higher precision, and improved inter-laboratory reproducibility, allowing for more realistic materialization of true biomarkers via validation studies in independent cohorts. We found a relatively small subset of molecular features that can be used to predict the chances of survival of hospitalized COVID-19 patients within the first day of admission, using a robust LC-MRM setup which is already available in many clinical laboratories.
HostingRepository	PanoramaPublic
AnnounceDate	2022-08-18
AnnouncementXML	Submission_2022-08-18_11:06:37.591.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Claudia Gaither
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	6495B Triple Quadrupole LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-16 20:08:06	ID requested
⏵ 1	2022-08-18 11:06:38	announced

Richard VR, Gaither C, Popp R, Chaplygina D, Brzhozovskiy A, Kononikhin A, Mohammed Y, Zahedi RP, Nikolaev EN, Borchers CH, Early Prediction of COVID-19 Patient Survival by Targeted Plasma Multi-Omics and Machine Learning. Mol Cell Proteomics, 21(10):100277(2022) [pubmed]

submitter keyword: COVID-19, SARS COV 2, mass spectrometry, MRM, plasma, proteomics, internal standards

Christoph Borchers
contact affiliation	Segal Cancer Proteomics Centre, McGill University
contact email	christoph.borchers@mcgill.ca
lab head
Claudia Gaither
contact affiliation	MRM Proteomics Inc.
contact email	cgaither@mrmproteomics.com
dataset submitter

Panorama Public dataset URI