PXD027897

PXD027897 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of hepatic expression signatures affected in ZHX2 liver conditional knockout mice
Description	The liver has an exceptional capacity for regeneration which is crucial for maintaining liver function. Since transcriptional regulation of genes controlling metabolism and cell division is a hallmark of liver regeneration (LR), we investigated the role of Zinc-finger and homeboxes 2 (ZHX2), a transcription factor critical for regulating liver postnatal gene expression and hepatic lipid hemostasis, in LR. Our results show that hepatocyte-specific Zhx2 knockout (Zhx2-KOhep) enhances LR after 2/3 partial hepatectomy in mice. Proteomics assays revealed higher mitochondrial oxidative phosphorylation (OXPHOS) in Zhx2-KOhep mouse livers. Oxygen consumption rate (OCR) and ATP generation assays confirmed the enhanced OXPHOS in Zhx2-KOhep mouse livers and human hepatocytes with ZHX2 knockdown.
HostingRepository	PRIDE
AnnounceDate	2023-10-17
AnnouncementXML	Submission_2023-10-17_04:12:06.068.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yanzhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-12 08:02:10	ID requested
⏵ 1	2023-10-17 04:12:06	announced

Dataset with its publication pending

submitter keyword: Mouse, ZHX2, Proteome sequencing, liver

ChunhongMa
contact affiliation	Cheeloo Medical College, Shandong University, Jinan, Shandong, China
contact email	machunhong@sdu.edu.cn
lab head
yanzhang
contact affiliation	School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, China
contact email	zhyk615@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD027897

PRIDE project URI

• PRIDE
  1. PXD027897
     1. Label: PRIDE project
     2. Name: Proteomic characterization of hepatic expression signatures affected in ZHX2 liver conditional knockout mice