PXD027826 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human RKO cells LC-MSMS (gel-based proteomics) |
Description | Tumor cells evade T cell-mediated immunosurveillance via the interaction between programmed death-1 (PD-1) ligand 1 (PD-L1) on tumor cells and PD-1 on T cells. Strategies disrupting PD-1/PD-L1 have shown clinical benefits in various cancers. However, the limited response rate prompts us to investigate the molecular regulation of PD-L1. Here we identify trafficking protein particle complex subunit 4 (TRAPPC4), a major player in vesicular trafficking, as a crucial PD-L1 regulator. TRAPPC4 interacts with PD-L1 in recycling endosomes, promoting RAB11-mediated recycling of PD-L1, and acting as a scaffold between PD-L1 and RAB11, thus replenishing its distribution on the tumor cell surface. |
HostingRepository | PRIDE |
AnnounceDate | 2021-08-15 |
AnnouncementXML | Submission_2021-08-15_06:27:35.208.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yimeng Ren |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-09 08:46:20 | ID requested | |
⏵ 1 | 2021-08-15 06:27:35 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Huamn,RKO cells,LC-MSMS |
Contact List
Jingyuan Fang |
contact affiliation | State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
contact email | jingyuanfang@sjtu.edu.cn |
lab head | |
Yimeng Ren |
contact affiliation | Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
contact email | renyimeng_SJTU@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027826
- Label: PRIDE project
- Name: Human RKO cells LC-MSMS (gel-based proteomics)