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PXD027826

PXD027826 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman RKO cells LC-MSMS (gel-based proteomics)
DescriptionTumor cells evade T cell-mediated immunosurveillance via the interaction between programmed death-1 (PD-1) ligand 1 (PD-L1) on tumor cells and PD-1 on T cells. Strategies disrupting PD-1/PD-L1 have shown clinical benefits in various cancers. However, the limited response rate prompts us to investigate the molecular regulation of PD-L1. Here we identify trafficking protein particle complex subunit 4 (TRAPPC4), a major player in vesicular trafficking, as a crucial PD-L1 regulator. TRAPPC4 interacts with PD-L1 in recycling endosomes, promoting RAB11-mediated recycling of PD-L1, and acting as a scaffold between PD-L1 and RAB11, thus replenishing its distribution on the tumor cell surface.
HostingRepositoryPRIDE
AnnounceDate2021-08-15
AnnouncementXMLSubmission_2021-08-15_06:27:35.208.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYimeng Ren
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-09 08:46:20ID requested
12021-08-15 06:27:35announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Huamn,RKO cells,LC-MSMS
Contact List
Jingyuan Fang
contact affiliationState Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
contact emailjingyuanfang@sjtu.edu.cn
lab head
Yimeng Ren
contact affiliationDivision of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
contact emailrenyimeng_SJTU@163.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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