PXD027811 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular vesicle proteome from cardiac muscle critical for protection against obesity in female mice |
Description | Dysregulation of ER has been linked with increased metabolic and cardiovascular disease risk. Uncovering the impact of ERα deficiency in specific tissues has implications for understanding the role ERα in normal physiology and disease, the increased disease risk in postmenopausal women, and the design of tissue-specific ERα-based therapies for a range of pathologies including cardiac disease and cancer. Cardiac myocyte-specific ER knockout mice (ERHKO) were generated to assess the role of ERα in the heart. Female ERHKO mice displayed a mild cardiac phenotype, but unexpectedly, the most striking phenotype was obesity in female ERHKO but not male ERHKO mice. We identified contractile dysfunction, metabolic and lipid dysregulation in hearts of female ERHKO mice. We also show that extracellular vesicles (EVs) collected from the perfusate from Langendorff-isolated hearts from female ERHKO mice contained distinct proteins with functions related to muscle, metabolic and fatty acid dysregulation. |
HostingRepository | PRIDE |
AnnounceDate | 2023-01-15 |
AnnouncementXML | Submission_2023-01-15_14:42:51.650.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | davidgreening |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-09 06:33:53 | ID requested | |
⏵ 1 | 2023-01-15 14:42:52 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: cardiac, heart, extracellular vesicle, tissue, obesity,human, proteome |
Contact List
davidgreening |
contact affiliation | Baker Heart and Diabetes Institute |
contact email | david.greening@baker.edu.au |
lab head | |
davidgreening |
contact affiliation | Baker Heart and Diabetes Inst. |
contact email | david.greening@baker.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027811
- Label: PRIDE project
- Name: Extracellular vesicle proteome from cardiac muscle critical for protection against obesity in female mice