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PXD027811

PXD027811 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExtracellular vesicle proteome from cardiac muscle critical for protection against obesity in female mice
DescriptionDysregulation of ER has been linked with increased metabolic and cardiovascular disease risk. Uncovering the impact of ERα deficiency in specific tissues has implications for understanding the role ERα in normal physiology and disease, the increased disease risk in postmenopausal women, and the design of tissue-specific ERα-based therapies for a range of pathologies including cardiac disease and cancer. Cardiac myocyte-specific ER knockout mice (ERHKO) were generated to assess the role of ERα in the heart. Female ERHKO mice displayed a mild cardiac phenotype, but unexpectedly, the most striking phenotype was obesity in female ERHKO but not male ERHKO mice. We identified contractile dysfunction, metabolic and lipid dysregulation in hearts of female ERHKO mice. We also show that extracellular vesicles (EVs) collected from the perfusate from Langendorff-isolated hearts from female ERHKO mice contained distinct proteins with functions related to muscle, metabolic and fatty acid dysregulation.
HostingRepositoryPRIDE
AnnounceDate2023-01-15
AnnouncementXMLSubmission_2023-01-15_14:42:51.650.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdavidgreening
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-09 06:33:53ID requested
12023-01-15 14:42:52announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: cardiac, heart, extracellular vesicle, tissue, obesity,human, proteome
Contact List
davidgreening
contact affiliationBaker Heart and Diabetes Institute
contact emaildavid.greening@baker.edu.au
lab head
davidgreening
contact affiliationBaker Heart and Diabetes Inst.
contact emaildavid.greening@baker.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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