PXD027784 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic approach for unravelling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica survival and virulence |
Description | Please provide an overall description of your study, think something similar in scope to the manuscript abstractCFIm25 is essential for recruitment of other polyadenylation factors, poly(A) site selection, pre-mRNA cleavage and poly(A) tail synthesis. We recently reported that EhCFIm25 silencing in Entamoeba histolytica, the protozoan responsible for amebic dysentery, affects trophozoite proliferation and death, and reduces parasite virulence, indicating its relevance as a new biochemical target in this human pathogen. Here, we performed a shotgun proteomic analysis to evidence the impact of EhCFIm25 silencing on protein expression that can explain the observed phenotype |
HostingRepository | PRIDE |
AnnounceDate | 2021-08-26 |
AnnouncementXML | Submission_2021-08-26_04:00:04.831.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD027784 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Rodolfo G Avila-Bonilla |
SpeciesList | scientific name: Entamoeba histolytica HM-1:IMSS-A; NCBI TaxID: 885318; |
ModificationList | No PTMs are included in the dataset |
Instrument | Synapt G2 MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-06 03:45:18 | ID requested | |
⏵ 1 | 2021-08-26 04:00:05 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: i.e. Human, Liver, Plntamoeba histolytica |
CFIm25 silencing |
polyadenylation |
proteomics |
virulenceasma, LC-MSMS |
Contact List
Laurence A. Marchat |
contact affiliation | Instituto Politécnico Nacional |
contact email | lmarchat@gmail.com |
lab head | |
Rodolfo G Avila-Bonilla |
contact affiliation | Instituto Politécnico Nacional |
contact email | avilab.r.g@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027784
- Label: PRIDE project
- Name: A proteomic approach for unravelling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica survival and virulence