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PXD027784

PXD027784 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA proteomic approach for unravelling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica survival and virulence
DescriptionPlease provide an overall description of your study, think something similar in scope to the manuscript abstractCFIm25 is essential for recruitment of other polyadenylation factors, poly(A) site selection, pre-mRNA cleavage and poly(A) tail synthesis. We recently reported that EhCFIm25 silencing in Entamoeba histolytica, the protozoan responsible for amebic dysentery, affects trophozoite proliferation and death, and reduces parasite virulence, indicating its relevance as a new biochemical target in this human pathogen. Here, we performed a shotgun proteomic analysis to evidence the impact of EhCFIm25 silencing on protein expression that can explain the observed phenotype
HostingRepositoryPRIDE
AnnounceDate2021-08-26
AnnouncementXMLSubmission_2021-08-26_04:00:04.831.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD027784
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterRodolfo G Avila-Bonilla
SpeciesList scientific name: Entamoeba histolytica HM-1:IMSS-A; NCBI TaxID: 885318;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt G2 MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-06 03:45:18ID requested
12021-08-26 04:00:05announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: i.e. Human, Liver, Plntamoeba histolytica
CFIm25 silencing
polyadenylation
proteomics
virulenceasma, LC-MSMS
Contact List
Laurence A. Marchat
contact affiliationInstituto Politécnico Nacional
contact emaillmarchat@gmail.com
lab head
Rodolfo G Avila-Bonilla
contact affiliationInstituto Politécnico Nacional
contact emailavilab.r.g@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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