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PXD027772

PXD027772 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA scalable, clinically severe pig model for Duchenne muscular dystrophy
DescriptionLarge animal models for Duchenne muscular dystrophy (DMD) are indispensible for preclinical evaluation of novel diagnostic procedures and treatment strategies. To evaluate functional consequences of Duchenne muscular dystrophy (DMD) in skeletal muscle and myocardium, we used a new genetically engineered dystrophin KO pig model displaying hallmarks of human DMD. Heart and skeletal muscle tissue samples of DMD pigs and wild-type (WT) controls at three different ages were analyzed by label-free proteomics.
HostingRepositoryPRIDE
AnnounceDate2021-12-01
AnnouncementXMLSubmission_2021-12-01_05:14:30.385.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterThomas Fröhlich
SpeciesList scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-05 10:03:01ID requested
12021-12-01 05:14:31announced
Publication List
Stirm M, Fonteyne LM, Shashikadze B, Lindner M, Chirivi M, Lange A, Kaufhold C, Mayer C, Medugorac I, Kessler B, Kurome M, Zakhartchenko V, Hinrichs A, Kemter E, Krause S, Wanke R, Arnold GJ, Wess G, Nagashima H, Hrabĕ de Angelis M, Flenkenthaler F, Kobelke LA, Bearzi C, Rizzi R, Bähr A, Reese S, Matiasek K, Walter MC, Kupatt C, Ziegler S, Bartenstein P, Fröhlich T, Klymiuk N, Blutke A, Wolf E, A scalable, clinically severe pig model for Duchenne muscular dystrophy. Dis Model Mech, 14(12):(2021) [pubmed]
Keyword List
submitter keyword: Duchenne muscular dystrophy, DMD, animal model, pig, proteomics
Contact List
Thomas Fröhlich
contact affiliationLudwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact emailfrohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliationLaboratory for Functional Genome Analysis Gene Center Munich Ludwig-Maximilians-Universität Munich (LMU) Feodor-Lynen-Str. 25 81377 Munich Germany
contact emailfrohlich@genzentrum.lmu.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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