Updated project metadata. The pathogenesis of idiopathic intracranial hypertension (IIH) is currently poorly understood. Speculations regarding the role of cerebrospinal fluid (CSF) protein biomarkers in understanding the pathomechanism of IIH needs to be studied using the high-throughput omics approaches.In this study we have performed an untargeted SWATH-MS proteomics approach to identify CSF biomarkers in IIH cases compared to control subjects.