PXD027747

PXD027747 is an original dataset announced via ProteomeXchange.

Title	Plasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
Description	We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated (49-127) TTR. The presence of S52P TTR was confirmed by proteomics. Knockout of alpha2-antiplasmin enhanced amyloid deposition.
HostingRepository	PRIDE
AnnounceDate	2021-12-27
AnnouncementXML	Submission_2021-12-27_08:36:01.481.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Graham Taylor
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 10:00:15	ID requested
⏵ 1	2021-12-27 08:36:02	announced

Slamova I, Adib R, Ellmerich S, Golos MR, Gilbertson JA, Botcher N, Canetti D, Taylor GW, Rendell N, Tennent GA, Verona G, Porcari R, Mangione PP, Gillmore JD, Pepys MB, Bellotti V, Hawkins PN, Al-Shawi R, Simons JP, Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis. Nat Commun, 12(1):7112(2021) [pubmed]

submitter keyword: Mouse, amyloidosis, transthyretin, heart, tongue

Graham W Taylor
contact affiliation	Wolfson Drug Discovery Unit Centre for Amyloidosis & Acute Phase Proteins Division of Medicine, Royal Free Campus University College London
contact email	graham.taylor@ucl.ac.uk
lab head
Graham Taylor
contact affiliation	University College London
contact email	graham.taylor@ucl.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD027747

PRIDE project URI

• PRIDE
  1. PXD027747
     1. Label: PRIDE project
     2. Name: Plasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.