PXD027747 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis. |
Description | We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated (49-127) TTR. The presence of S52P TTR was confirmed by proteomics. Knockout of alpha2-antiplasmin enhanced amyloid deposition. |
HostingRepository | PRIDE |
AnnounceDate | 2021-12-27 |
AnnouncementXML | Submission_2021-12-27_08:36:01.481.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Graham Taylor |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-05 10:00:15 | ID requested | |
⏵ 1 | 2021-12-27 08:36:02 | announced | |
Publication List
Slamova I, Adib R, Ellmerich S, Golos MR, Gilbertson JA, Botcher N, Canetti D, Taylor GW, Rendell N, Tennent GA, Verona G, Porcari R, Mangione PP, Gillmore JD, Pepys MB, Bellotti V, Hawkins PN, Al-Shawi R, Simons JP, Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis. Nat Commun, 12(1):7112(2021) [pubmed] |
Keyword List
submitter keyword: Mouse, amyloidosis, transthyretin, heart, tongue |
Contact List
Graham W Taylor |
contact affiliation | Wolfson Drug Discovery Unit Centre for Amyloidosis & Acute Phase Proteins Division of Medicine, Royal Free Campus University College London |
contact email | graham.taylor@ucl.ac.uk |
lab head | |
Graham Taylor |
contact affiliation | University College London |
contact email | graham.taylor@ucl.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027747
- Label: PRIDE project
- Name: Plasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.