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PXD027747

PXD027747 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
DescriptionWe have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated (49-127) TTR. The presence of S52P TTR was confirmed by proteomics. Knockout of alpha2-antiplasmin enhanced amyloid deposition.
HostingRepositoryPRIDE
AnnounceDate2021-12-27
AnnouncementXMLSubmission_2021-12-27_08:36:01.481.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGraham Taylor
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-05 10:00:15ID requested
12021-12-27 08:36:02announced
Publication List
Slamova I, Adib R, Ellmerich S, Golos MR, Gilbertson JA, Botcher N, Canetti D, Taylor GW, Rendell N, Tennent GA, Verona G, Porcari R, Mangione PP, Gillmore JD, Pepys MB, Bellotti V, Hawkins PN, Al-Shawi R, Simons JP, Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis. Nat Commun, 12(1):7112(2021) [pubmed]
Keyword List
submitter keyword: Mouse, amyloidosis, transthyretin, heart, tongue
Contact List
Graham W Taylor
contact affiliationWolfson Drug Discovery Unit Centre for Amyloidosis & Acute Phase Proteins Division of Medicine, Royal Free Campus University College London
contact emailgraham.taylor@ucl.ac.uk
lab head
Graham Taylor
contact affiliationUniversity College London
contact emailgraham.taylor@ucl.ac.uk
dataset submitter
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Dataset FTP location
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Repository Record List
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