PXD027746

PXD027746 is an original dataset announced via ProteomeXchange.

Title	Identification of differently expressed proteins in breast cancer progression
Description	In this study, we identified a threshold for “danger discrimination” in macrophages after sensing specific changes in protein expression at the surface of cells with an advanced premalignant phenotype. The identification of these “danger signals” could stimulate the development of novel targeted chemoprevention and immunoprophylactic strategies. Drugs could also be developed to lower the discrimination threshold and therefore eliminate more efficiently earlier stages of premalignacy. Besides the applications for cancer prevention, a better understanding of mechanisms selected for immune tolerance could also have implications for the management of auto-immune disorders.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_05:58:19.938.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Camille Jacqueline
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	6410 Triple Quadrupole LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 10:00:15	ID requested
⏵ 1	2022-02-17 05:58:20	announced

Jacqueline C, Dracz M, Boothman S, Minden JS, Gottschalk RA, Finn OJ, Identification of Cell Surface Molecules That Determine the Macrophage Activation Threshold Associated With an Early Stage of Malignant Transformation. Front Immunol, 12():749597(2021) [pubmed]

ProteomeXchange project tag: Cancer (B/D-HPP)

submitter keyword: 2D-DIGE, mass spectometry, breast cancer

Olivera J. Finn
contact affiliation	University of Pittsburgh, School of Medicine
contact email	ojfinn@pitt.edu
lab head
Camille Jacqueline
contact affiliation	University of Pittsburgh
contact email	camjacqueline.pro@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD027746

PRIDE project URI

• PRIDE
  1. PXD027746
     1. Label: PRIDE project
     2. Name: Identification of differently expressed proteins in breast cancer progression