PXD027745

PXD027745 is an original dataset announced via ProteomeXchange.

Title	The protection of Evodiamine against Ulcerative Colitis and Colorectal Cancer via anti-inflammation
Description	Evodiamine (Evo), a kind of alkaloid mostly extracted from Tetradium ruticarpum, which has many pharmacological functions, such as antidiarrheal, antiemetic, and antiulcer effects. In this study, the effects of Evo were investigated in DSS-induced ulcerative colitis (UC) mice and C57BL/6-ApcMinC/Gpt mice with colorectal cancer (CRC). The results showed Evo not only sup-pressed the weight loss and the shorthen of colon, decreased disease activity index (DAI) and ameliorated the pathological alteration of colon in UC mice, but also inhibited the numbers and sizes of colonic tumor of ApcMinC/Gpt mice. Meanwhiles, Evo regulated nuclear factor-kappa B (NF-κB) related signal pathways to mediate various cytokines such as interleukins (Ils), tumor necrosis factor-α (TNF-α) to achieve anti-inflammatory and anti-tumor effects. In SW480 and Caco cells, Evo reduced the cell viabilities, promoted the mitochondrial membrane potential (MMP) and caused the over-accumulation of intracellular reactive oxygen species (ROS). Theoretical evi-dences indicated Evo binding NF-κB may be useful to contain ordered domain (α helix) in NF-κB, which can induce NF-κB to perform its function. Our results provide experimental and theoretical evidence that Evo might be promising and effective treatments in clinics for UC and CRC.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-20_03:23:10.851.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yaqin zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 09:59:55	ID requested
⏵ 1	2022-05-20 03:23:11	announced

Zhang Y, Zhang Y, Zhao Y, Wu W, Meng W, Zhou Y, Qiu Y, Li C, inflammatory effects. Mol Med Rep, 25(5):(2022) [pubmed]

submitter keyword: Evodiamine, Ulcerative colitis, Colorectal cancer, inflammation, NF-κB

Di Wang
contact affiliation	School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, Jilin, 130012, China
contact email	jluwangdi@jlu.edu.cn
lab head
yaqin zhang
contact affiliation	jilin university
contact email	1713808629@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027745
     1. Label: PRIDE project
     2. Name: The protection of Evodiamine against Ulcerative Colitis and Colorectal Cancer via anti-inflammation