PXD027727

PXD027727 is an original dataset announced via ProteomeXchange.

Title	ASF1 acts with RIF1 to promote DNA end-joining in BRCA1 deficient cells
Description	RIF1 acts downstream of 53BP1 to coordinate DNA double strand break repair pathway choice between non-homologous end joining (NHEJ) and homologous recombination (HR). Here we identified ASF1 as an endogenous RIF1-associated protein. We showed that ASF1 forms complex with RIF1 and regulates RIF1-dependent functions in DNA damage response.
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_05:20:58.567.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhen Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 08:58:38	ID requested
⏵ 1	2022-06-09 05:20:59	announced

Tang M, Chen Z, Wang C, Feng X, Lee N, Huang M, Zhang H, Li S, Xiong Y, Chen J, Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells. J Biol Chem, 298(6):101979(2022) [pubmed]

submitter keyword: RIF1, TAP-MS, interactome, ASF1

Junjie Chen
contact affiliation	Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
contact email	jchen8@mdanderson.org
lab head
Zhen Chen
contact affiliation	The University of Texas MD Anderson Cancer Center
contact email	zchen6@mdanderson.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD027727

PRIDE project URI

• PRIDE
  1. PXD027727
     1. Label: PRIDE project
     2. Name: ASF1 acts with RIF1 to promote DNA end-joining in BRCA1 deficient cells