PXD027714

PXD027714 is an original dataset announced via ProteomeXchange.

Title	Proteomic discovery and verification for the screening of biomarkers in different stages of mycosis fungoides: a pilot study
Description	Mycosis fungoides (MF) is the most common T-cell lymphoma in cutaneous malignant lymphoma, which may involve multiple organs in the advanced stage with a poor prognosis. Till now, early identification of the disease is still urgent and also there is no optimal therapy for advanced MF. In the present study, quantitative proteomic analyses (Label Free Quantitation, LFQ) and a parallel reaction monitoring (PRM) assay were applied in tissue samples of different stages of MF and the control group, so as to conduct preliminary molecular analysis of the significantly expressed proteins which may involve in the pathogenesis of the disease. The results revealed that genes and proteins implicated in DNA replication initiation, nucleosome assembly, cell adhesion activity, together with the cellular component and molecules that connecting extracellular region part may be involved in the pathogenesis and metastasis of MF. Some special proteins expressed obviously differently from the early to advanced stage of MF, indicating that they may be the key molecules for the progression of the disease. We believe that proteomics is a powerful tool to identify potential biomarkers for diagnosis and these molecules may be promising therapeutic targets for MF. For that, further studies are still needed.
HostingRepository	PRIDE
AnnounceDate	2021-11-23
AnnouncementXML	Submission_2021-11-23_08:46:59.401.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	lu gan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	(18)O label at both C-terminal oxygens
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-05 05:46:11	ID requested
⏵ 1	2021-11-23 08:46:59	announced

Dataset with its publication pending

submitter keyword: Mycosis fungoides

Label Free Quantitation (LFQ)

Parallel Reaction Monitoring (PRM)

pathogenesis

treatment

hao chen
contact affiliation	Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College，Nanjing 210042, China.
contact email	ch76ch@163.com
lab head
lu gan
contact affiliation	Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	467091016@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD027714

PRIDE project URI

• PRIDE
  1. PXD027714
     1. Label: PRIDE project
     2. Name: Proteomic discovery and verification for the screening of biomarkers in different stages of mycosis fungoides: a pilot study