PXD027595

PXD027595 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS data of Extracellular Vimentin
Description	Angiotensin-converting enzyme 2 (ACE2) has been identified as a key entry receptor for SARS-CoV-2. The involvement of other cellular components that partake in viral entry appears to be likely but is not yet fully understood. Here we describe the identification of vimentin (VIM), an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), we identified VIM as a protein that binds to the SARS-CoV-2 spike (S) protein.
HostingRepository	PRIDE
AnnounceDate	2022-02-22
AnnouncementXML	Submission_2022-02-22_04:49:23.561.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chaoshuang Xia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-27 07:27:34	ID requested
⏵ 1	2022-02-22 04:49:24	announced

Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, M, ü, hlberger E, Costello CE, Rahimi N, Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A, 119(6):(2022) [pubmed]

submitter keyword: SARS-CoV-2, Vimentin, attachment factor, SARS-CoV-2 receptor, spike protein

Catherine E. Costello
contact affiliation	Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118
contact email	cecmsms@bu.edu
lab head
Chaoshuang Xia
contact affiliation	Boston University
contact email	csxia@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD027595

PRIDE project URI

• PRIDE
  1. PXD027595
     1. Label: PRIDE project
     2. Name: LC-MS/MS data of Extracellular Vimentin