PXD027581

PXD027581 is an original dataset announced via ProteomeXchange.

Title	Neuroprotective properties of Mesenchymal Stromal Cell–Derived Extracellular Vesicles in Models of Acute Brain Pathology
Description	Extracellular vesicles (EVs) of multipotent mesenchymal stromal cells (MSCs) in various studies have shown a wide range of cytoprotective effects, including neuroprotective ones. It is important to note that the therapeutic effect of EVs is observed regardless of the tissue from which MSCs were isolated. However, the mechanisms of the neuroprotective action of extracellular vesicles remain elusive. It is assumed that the proteins contained in EVs could make the main contribution to the therapeutic effects of EVs. The aim of this work was to study protein composition of EV obtained from MSCs in conjunction with the experiments on neuroprotective properties and mechanisms of the neuroprotective effects of EVs-MSC in in vitro and in vivo models of acute neurological diseases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:41:34.575.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sergey Kovalchuk
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-27 06:00:06	ID requested
1	2022-10-14 04:33:32	announced
⏵ 2	2023-11-14 07:41:35	announced	2023-11-14: Updated project metadata.

Turovsky EA, Golovicheva VV, Varlamova EG, Danilina TI, Goryunov KV, Shevtsova YA, Pevzner IB, Zorova LD, Babenko VA, Evtushenko EA, Zharikova AA, Khutornenko AA, Kovalchuk SI, Plotnikov EY, Zorov DB, Sukhikh GT, Silachev DN, Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations. Int J Biol Sci, 18(14):5345-5368(2022) [pubmed]

submitter keyword: MSC,Extracellular vesicles, neuroprotection

Sergey I. Kovalchuk
contact affiliation	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
contact email	xerx222@gmail.com
lab head
Sergey Kovalchuk
contact affiliation	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, RAS
contact email	xerx222@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD027581

PRIDE project URI

• PRIDE
  1. PXD027581
     1. Label: PRIDE project
     2. Name: Neuroprotective properties of Mesenchymal Stromal Cell–Derived Extracellular Vesicles in Models of Acute Brain Pathology