PXD027548

PXD027548 is an original dataset announced via ProteomeXchange.

Title	Global quantitative phosphoproteomic analysis and Mass spectrometry analysis of GCA effects on BMSCs.
Description	During aging, senescent cells accumulate in bone marrow and secrete the dysfunctional factors, termed senescence associated secretory phenotype (SASP), which is implied to regulate bone metabolism. To identify the key SASP factors in bone marrow that influence skeletal aging, we analyzed the dysregulated factors in the bone marrow supernatant from young and aged rat through mass spectrometry. In another hand, BMSCs treated with rGCA, transfection of siRNA-Plxnb2 or controls were subjected to global quantitative phosphoproteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:58:36.387.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ying mei
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-25 15:36:34	ID requested
1	2023-02-28 07:13:56	announced
⏵ 2	2023-11-14 07:58:37	announced	2023-11-14: Updated project metadata.

Peng H, Hu B, Xie LQ, Su T, Li CJ, Liu Y, Yang M, Xiao Y, Feng X, Zhou R, Guo Q, Zhou HY, Huang Y, Jiang TJ, Luo XH, A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis. Cell Metab, 34(8):1168-1182.e6(2022) [pubmed]

submitter keyword: Grancalcin, Skeletal aging, Bone marrow mesenchymal stem cells, Plexin-b2 pathway., Immune cells

Chang-Jun Li
contact affiliation	Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, PR China
contact email	lichangjun@csu.edu.cn
lab head
ying mei
contact affiliation	PTM BIO
contact email	1289467040@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD027548

PRIDE project URI

• PRIDE
  1. PXD027548
     1. Label: PRIDE project
     2. Name: Global quantitative phosphoproteomic analysis and Mass spectrometry analysis of GCA effects on BMSCs.