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PXD027499 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic characterization of media conditioned by embryonic sympathetic ganglia and dorsal root ganglia
DescriptionEmbryonic malignant transformation is concomitant to organogenesis, often affecting multipotent and migratory progenitors. Neuroblastoma (NB) is an emblematic example, arising from neural crest progenitors and characterized by a high heterogeneity and a widely disseminated clinical presentation. Metastatic triggers from the embryonic environment are suspected but yet unknown due to limited investigation access in patients and current models. Using combinations of ex vivo and in vivo models mimicking the embryonic context coupled to proteomic and transcriptomic analyses, we identify Olfactomedin1 (OLFM1) released by sympathetic derivatives at the core of a gene program promoting NB cells decohesion, primary tumor escape and dissemination.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterYohann Couté
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-07-22 02:40:59ID requested
12022-05-04 04:31:13announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Conditioned medium, Sympathetic ganglia, Dorsal root ganglia, Chicken, Mouse, nanoLC-MS/MS
Contact List
Yohann Couté
contact affiliationEDyP
contact emailyohann.coute@cea.fr
lab head
Yohann Couté
contact affiliationEDyP
contact emailyohann.coute@cea.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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