PXD027462

PXD027462 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	OGT-mediated AIMP2 O-GlcNAcylation promotes PARP1 overactivation in ageing-associated liver steatosis
Description	We identified 245 down-regulated and 343 up-regulated liver proteins in aged mice. Of note, the proteins Xbp1 and Bax, which are well recognized to be involved in the regulation of ageing, were also enriched, indicating that our proteomics results are credible. Moreover，some of enriched proteins are involved in cellular processes that are widely recognized as important for aging. Livers of ageing mice exhibited changed methylation, loss of proteostasis (protein folding alteration, decreased autophagy, and increased ubiquitination), increased apoptosis, dysregulated rhythmic process, and gut dysbiosis.
HostingRepository	jPOST
AnnounceDate	2022-07-21
AnnouncementXML	Submission_2022-09-18_03:06:52.278.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Renlong Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	L-methionine sulfoxide
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-21 02:25:59	ID requested
1	2022-07-20 08:00:06	announced
⏵ 2	2022-09-18 03:06:52	announced	2022-09-18: Updated FTP location.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: ageing-associated NAFLD, proteomics, AIMP2,PARP1, OGT, O-GlcNAcylation

submitter keyword: ageing-associated NAFLD, proteomics, AIMP2,PARP1, OGT, O-GlcNAcylation

Contact List

Yongzhan Nie
lab head
Renlong Li
contact affiliation	Xijing Digestive Proteomics Core, Four Military Medical University, China
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001196/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001196/