PXD027323

PXD027323 is an original dataset announced via ProteomeXchange.

Title	PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Tregs polarization
Description	Here, we discovered that the frequency of CD39+γδ Tregs, which positively correlated with poor prognosis, was significantly higher in right-sided colorectal cancer (RSCRC) than in the left-sided CRC (LSCRC). To explore the molecular mechanism leading to the difference of CD39+γδ Tregs derived from RSCRC and LSCRC, we collected fresh tissue samples of RSCRC with high expression of CD39+γδ Tregs and the LSCRC with low expression of CD39+γδ Tregs detected by flow cytometry and identified differential proteins by LC-MS based quantitative proteomic analysis with tandem mass tag (TMT)
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_05:21:17.834.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Zhan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-14 22:25:33	ID requested
⏵ 1	2022-02-17 05:21:19	announced

Zhan Y, Zheng L, Liu J, Hu D, Wang J, Liu K, Guo J, Zhang T, Kong D, Treg polarization. JCI Insight, 6(16):(2021) [pubmed]

submitter keyword: Human, Colorectal cancer, LC-MS/MS

Yang Zhan
contact affiliation	Department of colorectal cancer, Tianjin Medical University Cancer Institute and Hospital
contact email	zhanyang@tmu.edu.cn
lab head
Yang Zhan
contact affiliation	Tianjin Medical University Cancer Institute and Hospital
contact email	zhanyang@tmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD027323

PRIDE project URI

• PRIDE
  1. PXD027323
     1. Label: PRIDE project
     2. Name: PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Tregs polarization