PXD027299

PXD027299 is an original dataset announced via ProteomeXchange.

Title	Profiling of mouse brain acetylome and proteome
Description	Nε-Lysine acetylation is a reversible post-translational protein modification (PTM). In recent years, genetic analysis and animal model studies have shown that protein acetylation is closely related to the development of the nervous system and neurodegenerative diseases such as PD and AD. Here, we aim to profile the mouse brain acetylome by using FSAP, immunoaffinity precipitation of acetylpeptides and mass spectrometry method. We identified 1,591 acetylated proteins containing 4,182 acetylation modification sites in C57BL/6 mice brain. These proteins were involved in myelin sheath, mitochondrial inner membrane and neuron synapse. While KEGG enrichment analysis indicated that these proteins are associated with neurological diseases, such as Alzheimer's disease and Huntington disease. Taken together, we provided a comprehensive profile and clues for understanding the role of acetylated proteins in neuropathology such as neurogenesis, degeneration and aging.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:52:10.788.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuhua JI
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion Lumos; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-14 07:27:33	ID requested
1	2022-10-14 19:17:39	announced
⏵ 2	2023-11-14 08:52:11	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: acetylome, brain, mouse,Acetylation, proteome

Yuhua ji
contact affiliation	Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
contact email	tjiyuhua@126.com
lab head
Yuhua JI
contact affiliation	Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
contact email	tjiyuhua@126.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027299
     1. Label: PRIDE project
     2. Name: Profiling of mouse brain acetylome and proteome