PXD027259
PXD027259 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic characterization of primary and brain metastatic lung adenocarcinomas in a well-defined patient cohort |
| Description | Lung adenocarcinoma (LADC) is the most common subtype of non-small cell lung cancer (NSCLC). One major feature of disease progression is the metastatic spread to the central nervous system (CNS). Treatment regimens for brain metastases are limited, thus distant metastases remain the leading cause of tumour-associated deaths globally. The central aim of this paper was to investigate the differences of LADC and brain metastases with reference to fast and slowly progressing patients. Additionally, we elucidated the differences between patients with single versus multiple brain metastases. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_08:43:21.698.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD027259 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Nicole Woldmar |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-07-12 22:10:57 | ID requested | |
| 1 | 2023-03-11 08:13:47 | announced | |
| 2 | 2023-11-14 07:16:30 | announced | 2023-11-14: Updated project metadata. |
| ⏵ 3 | 2023-11-14 08:43:23 | announced | 2023-11-14: Updated project metadata. |
Publication List
| Woldmar N, Schwendenwein A, Kuras M, Szeitz B, Boettiger K, Tisza A, L, á, szl, ó V, Reiniger L, Bag, ó AG, Sz, á, ll, á, si Z, Moldvay J, Sz, á, sz AM, Malm J, Horvatovich P, Pizzatti L, Domont GB, R, é, nyi-V, á, mos F, Hoetzenecker K, Hoda MA, Marko-Varga G, Schelch K, Megyesfalvi Z, Rezeli M, D, ö, me B, Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases. ESMO Open, 8(1):100741(2023) [pubmed] |
| 10.6019/PXD027259; |
| Kuras M, Woldmar N, Kim Y, Hefner M, Malm J, Moldvay J, D, ö, me B, Fillinger J, Pizzatti L, Gil J, Marko-Varga G, Rezeli M, Proteomic Workflows for High-Quality Quantitative Proteome and Post-Translational Modification Analysis of Clinically Relevant Samples from Formalin-Fixed Paraffin-Embedded Archives. J Proteome Res, 20(1):1027-1039(2021) [pubmed] |
Keyword List
| submitter keyword: cancer progression, FFPE samples,lung adenocarcinoma, clinical proteomics, brain metastasis |
Contact List
| Gyorgy Marko-Varga | |
|---|---|
| contact affiliation | Department of Clinical Sciences, Division of Clinical Protein Science and Imaging, Lund University, Sweden |
| contact email | gyorgymarkovarga@hotmail.com |
| lab head | |
| Nicole Woldmar | |
| contact affiliation | Federal University of Rio de Janeiro (UFRJ) |
| contact email | nwoldmar@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD027259 |
| PRIDE project URI |
Repository Record List
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