PXD027186 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | GFP-DLC1 interactome in MCF7 breast cancer cells |
Description | The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. The aim of this project was to identify novel interaction partners, that could be involved in the regulation of DLC1 proteasomal degradation. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-20 |
AnnouncementXML | Submission_2022-05-20_02:11:32.277.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nicolas Nalpas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | methylated residue; phosphorylated residue; acetylated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-08 04:20:11 | ID requested | |
⏵ 1 | 2022-05-20 02:11:33 | announced | |
Publication List
Frey Y, Franz-Wachtel M, Macek B, Olayioye MA, Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Sci Rep, 12(1):5036(2022) [pubmed] |
Keyword List
submitter keyword: RhoGAP, DLC1, breast cancer, MCF7 |
Contact List
Monilola Olayioye |
contact affiliation | University of Stuttgart, Germany, Institute of Cell Biology and Immunology |
contact email | monilola.olayioye@izi.uni-stuttgart.de |
lab head | |
Nicolas Nalpas |
contact affiliation | Tuebingen University |
contact email | nalpas.nicolas@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD027186 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027186
- Label: PRIDE project
- Name: GFP-DLC1 interactome in MCF7 breast cancer cells