PXD027177

PXD027177 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis reveals low dose PARP inhibitor-induced differential protein expression in BRCA1-mutated high-grade serous ovarian cancer cells
Description	To detect the off-target effects of PARP inhibition, a quantitative mass spectrometry-based proteomic analysis was conducted of a BRCA1-mutated HGSOC cell line treated with low doses of two PARPi, Niraparib and Rucaparib.
HostingRepository	PRIDE
AnnounceDate	2022-04-15
AnnouncementXML	Submission_2022-04-15_14:02:33.450.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jesenia Perez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-07 21:46:52	ID requested
⏵ 1	2022-04-15 14:02:34	announced

Publication List

Perez JM, Twigg CAI, Guan W, Thomas SN, Proteomic Analysis Reveals Low-Dose PARP Inhibitor-Induced Differential Protein Expression in BRCA1-Mutated High-Grade Serous Ovarian Cancer Cells. J Am Soc Mass Spectrom, 33(2):242-250(2022) [pubmed]

Perez JM, Twigg CAI, Guan W, Thomas SN, Proteomic Analysis Reveals Low-Dose PARP Inhibitor-Induced Differential Protein Expression in BRCA1-Mutated High-Grade Serous Ovarian Cancer Cells. J Am Soc Mass Spectrom, 33(2):242-250(2022) [pubmed]

Keyword List

submitter keyword: ovarian cancer, tandem mass tags (TMT), mass spectrometry, proteomics, PARP inhibitor (PARPi)

submitter keyword: ovarian cancer, tandem mass tags (TMT), mass spectrometry, proteomics, PARP inhibitor (PARPi)

Contact List

Stefani N. Thomas
contact affiliation	Department of Laboratory Medicine and Pathology University of Minnesota School of Medicine
contact email	stefanit@umn.edu
lab head
Jesenia Perez
contact affiliation	University of Minnesota
contact email	perez888@umn.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD027177
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD027177

PRIDE project URI

Repository Record List

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